PFS may refer to:

• Provincial Forest Service, state civil service for forests in India

• Patellofemoral syndrome, a type of knee disorder
• Prefilled syringe, a syringe with a predetermined dosage of medication
• Prefrontal synthesis, in neurology, the conscious purposeful process of synthesizing novel mental images
• Progression-free survival, time without tumor progression in oncology
• Post-finasteride syndrome, a term associated with adverse effects that persist beyond the discontinuation of the medication finasteride

• Premium Fulfilment Services (PFS Group), National provider of 3PL solutions with operating companies in the US, UK and EU.
• Penang Free School, a well-recognized English school in Malaysia, in the state of Penang
• Philadelphia Folksong Society, a Philadelphia organization promoting folk music
• Princeton Friends School, a coeducational Quaker school in Princeton Township, New Jersey
• Property and Freedom Society, an organization devoted to the promotion of property rights

• Personal finance society, a professional body for financial advisors in the United Kingdom
• Personal Financial Specialist, a financial planning credential granted by the American Institute of Certified Public Accountants
• Primerica Financial Services, an independent financial services company in North America

• Perfect forward secrecy, a property in cryptography
• pfs:Write, an early PC word processor
• Planetary Fourier Spectrometer, an infrared spectrometer used by European Space Agency on their Venus Express Mission
• Playstation File System, the filesystem used on the PlayStation 2 hard drive
• Professional File System, a third-party filesystem used on the Amiga
• PlaysForSure, a marketing certification given by Microsoft to media players
• Prepare for Shipment, a status which indicates products are ready for shipment from Apple Online Store
• Pre-Feasibility Study, an important preliminary study to determine if a mining project is economically feasible

• Peace and Friendship Stadium, an Indoor sports Arena in Piraeus, Athens, Greece
• Picture Frame Seduction, a Welsh punk rock band
• Port security (Port Facility Security)
• Pha̍k-fa-sṳ, an orthography designed for the Hakka Chinese language
• Puta falta de sacanagem, an expression related to the Brazilian rock band Restart