Meloxicam/rizatriptan, sold under the brand name Symbravo, is a fixed-dose combination medication used for the treatment of migraine.[1] It is a combination of meloxicam, a nonsteroidal anti-inflammatory medication; and rizatriptan (as rizatriptan benzoate), a serotonin (5-HT) 1B/1D receptor agonist (triptan).[1] The ratio in Symbravo is 20 mg meloxicam to 10 mg rizatriptan. It is taken by mouth.[1]
Meloxicam/rizatriptan was approved for medical use in the United States in January 2025.[2]
Medical uses
Meloxicam/rizatriptan is indicated for the acute treatment of migraine with or without aura in adults.[1][3]
Society and culture
Legal status
Meloxicam/rizatriptan was approved for medical use in the United States in January 2025.[2]
References
- ^ a b c d e "SYMBRAVO (meloxicam and rizatriptan) tablets, for oral use" (PDF). Axsome Therapeutics, Inc. U.S. Food and Drug Administration.
- ^ a b "Axsome Therapeutics Announces FDA Approval of Symbravo (meloxicam and rizatriptan) for the Acute Treatment of Migraine with or without Aura in Adults" (Press release). Axsome Therapeutics. 30 January 2025. Retrieved 7 February 2025 – via GlobeNewswire.
- ^ Karsan N, Goadsby PJ (September 2022). "New Oral Drugs for Migraine". CNS Drugs. 36 (9): 933–949. doi:10.1007/s40263-022-00948-8. PMC 9477894. PMID 36031682.
External links
- Clinical trial number NCT03896009 for "Maximizing Outcomes in Treating Acute Migraine (MOMENTUM)" at ClinicalTrials.gov
- Clinical trial number NCT04163185 for "Initiating Early Control of Migraine Pain and Associated Symptoms (INTERCEPT)" at ClinicalTrials.gov
| pyrazolones / pyrazolidines | |
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| salicylates | |
| acetic acid derivatives and related substances | |
| oxicams | |
| propionic acid derivatives (profens) |
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| n-arylanthranilic acids (fenamates) | |
| COX-2 inhibitors (coxibs) | |
| other | |
| NSAID combinations | |
Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; †withdrawn drugs; ‡veterinary use. | |
