Little Italy is a general name for an ethnic enclave populated primarily by Italians or people of Italian ancestry, usually in an urban neighborhood.

Little Italy may also refer to:

• Little Italy, Melbourne

• Little Italy, Edmonton, Alberta
• Little Italy, Montreal
• Little Italy, Ottawa
• Little Italy, Toronto
• Little Italy, Vancouver
• Little Italy, Windsor
• Little Italy, Winnipeg

• Little Italy, Clerkenwell, London

• Little Italy, Arkansas
• Little Italy, San Diego, California
• Little Italy, Bridgeport, Connecticut
• Little Italy, Waterbury, Connecticut
• Little Italy, Wilmington, Delaware
• Little Italy, Chicago, Illinois
• Little Italy, Baltimore, Maryland
• Little Italy, Omaha, Nebraska
• Little Italy, Paterson, New Jersey
• Little Italy, Manhattan, New York
• Little Italy, Syracuse, New York
• Little Italy, Connellsville, Pennsylvania
• Little Italy, Cleveland, Ohio
• Little Italy, Clay County, West Virginia
• Little Italy, Randolph County, West Virginia

• Little Italy (1921 film), an American comedy film directed by George Terwilliger and written by Tom McNamara and Peter Milne
• Little Italy (1978 film), an Italian "poliziottesco"-comedy film directed by Bruno Corbucci and the fourth chapter in the Nico Giraldi film series
• Little Italy (2018 film), an English-language romantic comedy film starring Emma Roberts and Hayden Christensen
• "Little Italy" (Northern Exposure), a 1995 television episode

• Maggiano's Little Italy
• In Little Italy, a 1909 film directed by D. W. Griffith
• Lil Italy, an American rapper