The following is a list of people from Waterford, Ireland.

• Richard Chenevix (1697–1779), Church of Ireland bishop
• Charles Joseph Henderson (1924–2006), Auxiliary Bishop of Southwark (UK) and Bishop of Tricala
• Tobias Kirby (1804–1895), Rector of the Irish College Rome 1850–1891; archbishop of Ephesus 1885
• Michael O'Hickey (1860–1916), priest, Professor of Irish at Maynooth University
• Nicholas Quemerford (c. 1554–1599), Irish Jesuit priest
• Edmund Ignatius Rice (1762–1844), religious founder
• Michael Sheehan (1870–1945), Archbishop of Germia; author, professor
• Luke Wadding (1588–1657), theologian, historian, patriot
• Michael Wadding (1591–1644),Jesuit priest and missionary to New Spain
• Nicholas Wiseman (1802–1865), cardinal

• Jim Beglin (born 1963), soccer player
• Craig Breen (1990–2023), rally driver
• Niamh Briggs (born 1984), Irish international rugby player
• Locky Byrne (1913–1941), hurler
• Tom Cheasty (1934–2007), hurler
• Paddy Coad (1920–1992), soccer player
• Tom Cunningham (1931–2022), hurler
• Pat Fanning (1918–2010), hurler, GAA President
• Mick Flannelly (1930–2021), hurler
• Andy Fleming (1916–2011), hurler
• Austin Flynn (1933–2021), hurler
• Philly Grimes (1929–1989), hurler
• Larry Guinan (born 1937), hurler
• Alfie Hale (born 1939), soccer player
• Noel Hunt (born 1982), Irish international soccer player
• Stephen Hunt (born 1981), Irish international soccer player
• John Keane (1917–1975), hurler
• Sean Kelly (born 1956), Ireland's most successful racing cyclist, one of the top eight cyclists of all time
• Martin Óg Morrissey (born 1934), hurler
• Christy Moylan (1916–1996), hurler
• Daryl Murphy (born 1983), Irish international soccer player
• Johnny O'Connor (1928–2010), hurler
• Peter O'Connor (1872–1957), athlete, Olympic champion
• John O'Shea (born 1981), Irish international soccer player
• Ciarán Power (born 1976), Olympic Games cyclist 2000, 2004
• Ned Power (1929–2007), hurler
• Seamus Power (1929–2016), hurler
• Susan Smith-Walsh (born 1971), Olympic athlete
• John Treacy (born 1957), Olympic athlete, world champion
• Frankie Walsh (1936–2012), hurler
• Patricia Walsh (born 1960), Olympic athlete
• Charlie Ware (1933–2013), hurler
• Jim Ware (1908–1983), hurler
• Thomas Barr (born 1992), Olympic athlete
• Jessie Barr (born 1989), Olympic athlete

• Mary Butler (born 1966), politician
• William Charles Bonaparte-Wyse (1826–1892), soldier
• Denis Cashman (1843–1897), Fenian, patriot
• Hugh Collender, Young Irelander, businessman
• Ciara Conway (born 1980), former Labour Party politician
• Paudie Coffey (born 1969), Minister of State for Housing and planning from 2014 to 2016
• Edward Collins (1941–2019), Irish Fine Gael politician
• Maurice Cummins (born 1953), Irish Fine Gael politician
• David Cullinane
• Lorraine Clifford-Lee
• John Condon, boy soldier, youngest Allied soldier to die in First World War
• Martin Cullen (born 1954), former Fianna Fail politician
• John Deasy
• Austin Deasy (1936–2017), Irish Fine Gael politician
• Frank Edwards, left wing activist, Spanish Civil War fighter
• Francis Hearn, patriot
• John Hearne (1893–1969), orator, lawyer and architect of the 1937 Irish Constitution, or Bunracht na hÉireann
• William Hobson (1792–1842), first Governor of New Zealand
• Brendan Kenneally
• Billy Kenneally (1925–2009), Fianna Fail politician, twice Mayor of Waterford
• Thomas Kyne (1905–1981), Labour Party politician
• George Lennon (1900–1991), vice commanding officer, West Waterford I.R.A. (1919–1922)
• Patrick Little (1884–1963), Fianna Fail politician, Minister for Posts and Telegraphs
• Thaddeus Lynch (1901–1966), Fine Gael politician
• Thomas Francis Meagher (1823–1867), patriot, conceived the Irish tricolour
• Thomas Meagher (1796–1874), Irish politician and businessman
• Richard Mulcahy, (1886–1971), Irish Army C.O.C., Fine Gael politician
• Ann Ormonde (born 1935), former Irish Fianna Fail politician
• William Palliser (1830–1882), politician, inventor
• John Paul Phelan (born 1978), politician
• John Redmond (1856–1918), leader of the Irish Party in Westminster
• Frederick Roberts, 1st Earl Roberts (1832–1914), British Army C.O.C.
• Thomas Sexton (1848–1932), journalist, financial expert, nationalist politician and Member of Parliament
• Richard Lalor Shiel (1791–1851), Orator, M.P
• Alfred Webb (1834–1908), President of the 1894 Indian National Congress and MP for West Waterford

• Lucien Bonaparte-Wyse (1845–1909), entomologist
• Robert Boyle (1627–1691), physicist
• Richard J. Ussher (1841–1913), ornithologist
• Ernest Walton (1903–1995), Nobel Laureate (Physics 1951)

• Keith Barry (born 1976), magician, mentalist, illusionist
• Carrie Crowley, TV personality
• Teresa Deevy (1894–1963), playwright
• Val Doonican, entertainer
• Seán Dunne, poet
• Fiona Glascott
• Dorothea Jordan (1761–1816), actress; mistress of King William IV of the United Kingdom
• Charles Kean, Shakespearean actor
• Anna Manahan (1924–2009), actress
• Gerardine Meaney (born 1962), feminist critic
• Gilbert O'Sullivan, singer-songwriter
• Patrick C. Power, writer and historian
• Hal Roach, comedian
• Frank Ryan (1900–1965), tenor
• William Vincent Wallace (1814–1865), opera composer

• Eugene Byrne (born 1959), author, journalist
• Risteard De Hindeberg (1863–1916), priest, Irish language activist, author, musician
• Grattan Flood (1857–1928), musicologist and historian
• Valentine Greatrakes (1628–1682), 17th-century healer
• John Hogan (1800–1858), sculptor
• Donnchadh Ruadh Mac Conmara (1715–1810), teacher, poet
• Ellen Organ (1903–1908), saintly child known as "Little Nellie of Holy God"
• Thomas Sautelle Roberts (c. 1749–1778), landscape artist
• Mary Strangman (1872–1943), doctor, public health advocate and women's suffragist.