De Klerk, Klerk, De Klerck, Deklerck or Klerck is surname of Dutch and Frisian origin.

De Klerk

• AJ de Klerk (born 1991), Namibian rugby player
• Bob de Klerk (born 1961), Dutch football player and manager
• Brent Deklerck (born 2006), Belgian gymnast
• Evette de Klerk (born 1965), South African sprinter
• Faf de Klerk (born 1991), South African rugby player
• Michel de Klerk (1884–1923), Dutch architect
• F. W. de Klerk (1936–2021), President of South Africa
• Jade de Klerk (born 1999), South African cricketer
• Jan de Klerk (1903–1979), South African politician, father of F.W.
• Jan de Klerk (rugby union) (born 1991), South African rugby player
• Marike de Klerk (1937–2001), South African politician, former wife of F.W. de Klerk
• Michel de Klerk (1884–1923), Dutch architect
• Nadine de Klerk (born 2000), South African cricketer
• Peter de Klerk (1935–2015), South African racing driver
• Rossouw de Klerk (born 1989), South African rugby player
• Thom de Klerk (1912-1966), Dutch bassoonist
• Veronica de Klerk (born 1947), Namibian women's rights activist

• Doctor Paulos de Klerk, a character in James Rollins and Grant Blackwood's novel The Kill Switch (2014)

• Barbara Klerk (born 1989), Belgian figure skater
• Sander Jan Klerk (born 1982), Dutch actor, singer

• Carl-Gustaf Klerck (1885–1976), Swedish Olympic fencer
• Hendrick de Klerck (c.1560–1630), Flemish painter
• Reynier de Klerck (1710–1780), Governor-General of the Dutch East Indies