JME or Jme may refer to:

• Jme (born 1985), English grime MC and record producer
• J-Me (born 1985), Burmese rapper

• JME Molecule Editor, a Molecule Editor applet
• jMonkeyEngine, a Java scenegraph API

• Juvenile myoclonic epilepsy, a neurological disease
• Jme, a North American streaming service and successor to TV Japan