Homicide is the act of killing of another human.

Homicide may also refer to:

• Homicide (wrestler) (born 1977), American professional wrestler, born as Nelson Erazo
• DJ Homicide (born 1970), American DJ formerly of Sugar Ray

• Homicide (1949 film), an American film directed by Felix Jacoves
• Homicide (1991 film), an American film by David Mamet
• Homicide (Australian TV series), a 1964–1977 Australian police procedural series

• Homicide: A Year on the Killing Streets (1991), a non-fiction crime book by David Simon
  • Homicide: Life on the Street, a 1993–1999 American TV series inspired by David Simon's book
    • Homicide: The Movie (2000), a TV movie sequel to the series

• "Homicide" (song), a song by Logic from his album Confessions of a Dangerous Mind
• "Homicide", a song by 999 from Separates
• "Homicide", a song by the German rapper Casper from his EP Grundstein
• "Homicide", a song by Wiz Khalifa from mixtape called Cabin Fever
• "Homicide", a song from the soundtrack of Danganronpa 2: Goodbye Despair
• Homixide Gang, a rap duo signed to Playboi Carti's Opium label