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HIV Tat-specific factor 1 is a protein that in humans is encoded by the HTATSF1 gene.[5][6]

Function

Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immunodeficiency virus-1 (HIV-1) Tat predominantly stimulates elongation and interacts with the trans-acting responsive (TAR) RNA element. Tat is essential for HIV replication.[6]

HTATSF1 has also been shown to be involved in intron retention, and is associated with splicing of mRNAs that encode ribosomal proteins.[7] It is also associated with a naïve pluripotent state, although the relationship is complex and is strongly affected by other pluripotency factors such as Nanog and KLF2.[7]

Interactions

HTATSF1 has been shown to interact with SUPT5H[8] and GTF2F2.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102241Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067873Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhou Q, Sharp PA (November 1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
  6. ^ a b "Entrez Gene: HTATSF1 HIV-1 Tat specific factor 1".
  7. ^ a b Corsini NS, Peer AM, Moeseneder P, Roiuk M, Burkard TR, Theussl HC, Moll I, Knoblich JA (April 2018). "Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation". Cell Stem Cell. 22 (4): 543–558.e12. doi:10.1016/j.stem.2018.03.002. ISSN 1934-5909. PMID 29625069.
  8. ^ a b Kim JB, Yamaguchi Y, Wada T, Handa H, Sharp P A (September 1999). "Tat-SF1 protein associates with RAP30 and human SPT5 proteins". Mol. Cell. Biol. 19 (9): 5960–8. doi:10.1128/mcb.19.9.5960. ISSN 0270-7306. PMC 84462. PMID 10454543.

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