Glutarimide is the organic compound with the formula (CH2)3(CO)2NH. It is a white solid. The compound forms upon dehydration of the amide of glutaric acid.[2]
Glutarimide is sometimes called 2,6-piperidinedione. It is the core of a variety of drugs, including lenalidomide, a medication used to treat anemia and multiple myeloma;[3] and cycloheximide, a potent inhibitor of protein synthesis.[4]
References
- ^ Glutarimide - Sigma-Aldrich
- ^ Paris, G.; Berlinguet, L.; Gaudry, R.; English, Jr., J.; Dayan, J. E. (1957). "Glutaric Acid and Glutarimide". Organic Syntheses. 37: 47. doi:10.15227/orgsyn.037.0047.
- ^ "A to Z List of Cancer Drugs: Lenalidomide". National Cancer Institute. 1 September 2022. Retrieved 5 August 2024.
- ^ Sisler, Hugh D.; Siegel, Malcolm R. (1967). "Cycloheximide and Other Glutarimide Antibiotics". Mechanism of Action. pp. 283–307. doi:10.1007/978-3-642-46051-7_21. ISBN 978-3-642-46053-1.