Game On may refer to:

• Game On (2002 game show), an American game show
• Game On! (2020 game show), an American game show
• Game On (British TV series), a 1995–1998 sitcom
• Game On (Canadian game show), a 1998–2000 game show
• Game On (Canadian TV series), a 2015 comedy series
• Game: On, a 2004 live action and machinima short film for Volvo Cars
• "Game On", a 2010 promotional music video for the web series The Guild
• Game On, a 2016 YouTube video series by Tom Scott
• Game On, a 2024 Taiwanese television film series starring George Hu and Amanda Chou
• Game On (film), a 2024 Indian Telugu-language film

• "Game On" (Aaron Stone)
• "Game On" (Hit the Floor)
• "Game On" (Homeland)
• "Game On" (Rules of Engagement)
• "Game On" (Switched at Birth)
• "Game On" (The West Wing)

• Game On, Founded by Owen Ng in 2022. Game On is a Hong Kong Student-led organization and platform, providing sports opportunities to underprivileged children in Hong Kong

• Game On, a 2009 novel in the High School Musical book series

• Game On! (album), by Tina Guo, 2017
• Game On (EP), by the James Barker Band, 2017
• "Game On" (song), by Catatonia, 1998
• "Game On!", a song by Waka Flocka Flame featuring Good Charlotte from the Pixels film soundtrack, 2015

• Game On (exhibition), an international touring exhibition on the history of video games
• Game-On, a series of conferences on simulation and AI in computer games
• Game On Expo, an annual gaming convention in Phoenix, Arizona, US
• Game On! USA, a gaming magazine published by Viz Media in 1996
• Game On!, a 2012 video game podcast on the TWiT network