G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene.[5] The receptor has been shown to bind cholesin/C17orf50, a gut-derived hormone that is secreted from the intestine in response to dietary cholesterol absorption. In response to cholesin binding, GPR146 signaling inhibit cholesterol synthesis. [6] Consistent with this interaction, murine genetic disruption of GPR146 lowers serum cholesterol and reduces atherosclerotic aortic lesions.[7] GPR146 has also been identified as a possible receptor for C-peptide.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164849 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044197 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: GPR146 G protein-coupled receptor 146".
- ^ Hu X, Chen F, Jia L, Long A, Peng Y, Li X; et al. (2024). "A gut-derived hormone regulates cholesterol metabolism". Cell. 187 (7): 1685-1700.e18. doi:10.1016/j.cell.2024.02.024. PMID 38503280.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Yu H, Rimbert A, Palmer AE, Toyohara T, Xia Y, Xia F; et al. (2019). "GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis". Cell. 179 (6): 1276-1288.e14. doi:10.1016/j.cell.2019.10.034. PMC 6889877. PMID 31778654.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Yosten GL, Kolar GR, Redlinger LJ, Samson WK (11 July 2013). "Evidence for an interaction between proinsulin C-peptide and GPR146". The Journal of Endocrinology. 218 (2): B1-8. doi:10.1530/JOE-13-0203. PMID 23759446.
Further reading
- Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
- Gloriam DE, Schiöth HB, Fredriksson R (Apr 2005). "Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship". Biochimica et Biophysica Acta (BBA) - General Subjects. 1722 (3): 235–46. doi:10.1016/j.bbagen.2004.12.001. PMID 15777626.
