Expedition 73 will be the 73rd long-duration expedition to the International Space Station (ISS). The expedition will begin with the departure of Soyuz MS-26, expected to take place in mid-April 2025. Takuya Onishi of the Japan Aerospace Exploration Agency (JAXA) will serve as the commander of the expedition, the third JAXA astronaut to take command of the station.^[1] It will continue the extensive scientific research conducted aboard the ISS, focusing on various fields, including biology, human physiology, physics, and materials science. The crew members will also maintain and upgrade the space station systems.

Flight	Crew member	Increment 73a	Increment 73b	Increment 73c	Increment 73d
		20 Apr-Jul 2025 (planned)	Jul 2025 (planned)	Jul-27 Nov 2025 (planned)	27 Nov-8 Dec 2025 (planned)
Soyuz MS-27 (planned)	Sergey Ryzhikov, Roscosmos Third spaceflight	Flight Engineer
	Alexey Zubritsky, Roscosmos First spaceflight	Flight Engineer
	Jonny Kim, NASA First spaceflight	Flight Engineer
SpaceX Crew-10 (planned)	Anne McClain, NASA Second spaceflight	Flight Engineer		Off Station
	Nichole Ayers, NASA First spaceflight	Flight Engineer		Off Station
	Takuya Onishi, JAXA Second spaceflight	Commander		Off Station
	Kirill Peskov, Roscosmos First spaceflight	Flight Engineer		Off Station
SpaceX Crew-11 (planned)	TBA	Off Station	Flight Engineer
	TBA	Off Station	Flight Engineer
	TBA	Off Station	Flight Engineer
	Oleg Platonov, Roscosmos First spaceflight	Off Station	Flight Engineer
Soyuz MS-28 (planned)	Sergey Kud-Sverchkov, Roscosmos Second spaceflight	Off Station			Flight Engineer
	Sergey Mikayev, Roscosmos First spaceflight	Off Station			Flight Engineer
	Christopher Williams, NASA First spaceflight	Off Station			Flight Engineer