E Street is the fifth of a sequence of alphabetical streets in many cities.

It may refer to:

• E Street (TV series), an Australian television soap opera

• Washington DC:
  • E Street Expressway
• The E Street Band, known for their long association with Bruce Springsteen, named after E St, Belmar, New Jersey.
• Bayfront/E Street station, known also as E Street, trolley station in San Diego, California