UDP-N-acetylglucosamine—undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.33, UDP-N-acetylglucosamine:undecaprenyl-phosphate GlcNAc-1-phosphate transferase, WecA, WecA transferase, UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase, GlcNAc-P-P-Und synthase, GPT, TagO, UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase, UDP-N-acetyl-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetylglucosaminephosphotransferase) is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-alpha-D-glucosaminephosphotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- UDP-N-acetyl-alpha-D-glucosamine + ditrans, octacis-undecaprenyl phosphate UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans, octacis-undecaprenol
This enzyme catalyses the synthesis of ditrans, octacis-undecaprenyl-N-acetyl-alpha-D-glucosaminyl diphosphate.
References
- ^ Al-Dabbagh B, Mengin-Lecreulx D, Bouhss A (November 2008). "Purification and characterization of the bacterial UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase WecA". Journal of Bacteriology. 190 (21): 7141–6. doi:10.1128/jb.00676-08. PMC 2580700. PMID 18723618.
- ^ Lehrer J, Vigeant KA, Tatar LD, Valvano MA (April 2007). "Functional characterization and membrane topology of Escherichia coli WecA, a sugar-phosphate transferase initiating the biosynthesis of enterobacterial common antigen and O-antigen lipopolysaccharide". Journal of Bacteriology. 189 (7): 2618–28. doi:10.1128/jb.01905-06. PMC 1855806. PMID 17237164.
- ^ Rush JS, Rick PD, Waechter CJ (March 1997). "Polyisoprenyl phosphate specificity of UDP-GlcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase from E.coli". Glycobiology. 7 (2): 315–22. doi:10.1093/glycob/7.2.315. PMID 9134438.
- ^ Soldo B, Lazarevic V, Karamata D (July 2002). "tagO is involved in the synthesis of all anionic cell-wall polymers in Bacillus subtilis 168". Microbiology. 148 (Pt 7): 2079–87. doi:10.1099/00221287-148-7-2079. PMID 12101296.
External links
- UDP-N-acetylglucosamine---undecaprenyl-phosphate+N-acetylglucosaminephosphotransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
