David or Dave Lewis may refer to:

• A. David Lewis (born 1977), American comic writer and scholar of religion and literature
• David Lewis (anthropologist) (born 1960), English scholar of development
• David Lewis (lawyer) (c. 1520–1584), Welsh civil lawyer and first Principal of Jesus College, Oxford
• David Lewis (philosopher) (1941–2001), American philosopher
• David Lewis (psychologist) (born 1942), English neuropsychologist
• David A. Lewis, American psychiatrist and neuroscientist
• David C. Lewis (physician) (1935–2020), addictions treatment and drug policy expert
• David Levering Lewis (born 1936), American historian and biographer
• David Malcolm Lewis (1928–1994), English ancient historian
• David W. Lewis (lawyer) (1815–1885), American agriculturalist and Confederate Georgian politician
• David W. Lewis (mathematician) (1944–2021), Manx mathematician known for his contributions to quadratic forms theory

• David Lewis (American actor) (1916–2000), American actor
• David Lewis (Canadian actor) (born 1976), Canadian actor
• David Lewis (producer) (1903–1987), American film producer

• David Lewis, FAIA, American architect and co-founder of Urban Design Associates
• David J. Lewis (born 1966), American architect, founding partner with Lewis.Tsurumaki.Lewis (LTL Architects)

• Dave Lewis (businessman) (born 1965), English businessman
• David Lewis (designer) (1939–2011), British industrial designer
• David Lewis (English merchant) (1823–1885), English merchant and philanthropist
• David Edward Lewis (1866–1941), known as Dafydd Lewis, Welsh-born Australian businessman and philanthropist
• David S. Lewis (1917–2003), American aerospace engineer and engineering industry executive

• David Lewis (Anglican priest, born 1760) (1760–1850), Welsh Anglican priest and Rector of Garthbeibio, Montgomeryshire
• David Lewis (Archdeacon of Carmarthen) (1839–1901), British Anglican priest and Archdeacon of Carmarthen
• David Lewis (Jesuit priest) (1616–1679), Welsh Catholic priest and martyr
• David Lewis (priest, born 1814) (1814–1895), Welsh Anglican priest who converted to Catholicism

• Dave Lewis (American musician) (1938–1998), African-American Seattle rock musician
• Dave Lewis (Northern Irish musician) (born 1951), Northern Irish singer-songwriter
• David Lewis (Australian musician) (born c. 1960), Australian jazz and pop musician
• David Lewis (singer) (born 1958), American lead singer for the R&B group Atlantic Starr
• David C. Lewis (musician) (1940–2021), American keyboardist and composer

• Dave Lewis (politician) (born 1942), American state legislator in Montana
• David Lewis (British MP) (died 1872), British Member of Parliament for Carmarthen
• David Lewis (lord mayor) (born 1947), British solicitor and Lord Mayor of London
• David Lewis (Canadian politician) (1909–1981), Canadian politician and lawyer, leader of the New Democratic Party
• David Lewis, 1st Baron Brecon (1905–1976), Welsh businessman and Conservative politician
• David Chester Lewis (1884–1975), American lawyer, politician, and judge
• David John Lewis (1869–1952), American congressman and state politician in Maryland
• David P. Lewis (1820–1884), American Confederate politician and Governor of Alabama
• David R. Lewis (born 1971), American state legislator in North Carolina

• Dave Lewis (linebacker) (1954–2020), American football linebacker
• Dave Lewis (punter) (born 1945), American football punter
• David Lewis (American football) (born 1961), American football tight end

• Dai Lewis (footballer) (1912–?), Welsh international footballer
• Dave Lewis (footballer), UK footballer for Cheltenham Town F.C.
• David Morral Lewis (1864–1925), Welsh international footballer

• Dai Lewis (1866–1943), Welsh rugby union forward
• Dave Lewis (rugby union) (born 1989), Gloucester rugby scrum-half
• David Lewis (rugby league), Welsh rugby league footballer

• Dave Lewis (ice hockey) (born 1953), Canadian hockey player and coach
• Dave Lewis (racing driver) (1881–1928), American racecar driver
• David Lewis (bobsleigh) (born 1936), British Olympic bobsledder
• David Lewis (Zimbabwean cricketer) (1927–2013), Zimbabwean cricketer
• David Lewis (cricketer, born 1940), Welsh cricketer
• David Lewis (sport shooter) (1879–1966), British Olympic shooter
• David Lewis (tennis) (born 1964), New Zealand tennis player

• David Lewis, co-writer with his wife Beverly Lewis
• David Lewis (poet) (1682–1760), British poet
• David Emrys Lewis (1887–1954), Welsh poet and journalist

• David Lewis (adventurer) (1917–2002)
• David "Robber" Lewis (1790–1820), American criminal
• David Thomas Lewis (1912–1983), US appeal judge
• David Lewis (Indiana judge) (1909–1985), of the Indiana Supreme Court
• Death of David Glenn Lewis (1953–1993), unresolved crime

• David Maybury-Lewis (1929–2007), British anthropologist