DOS 8 or DOS-8 may refer to:
- DR-DOS 8.0, a version of DR-DOS distributed by DeviceLogics in 2004
- MS-DOS 8.0, the MS-DOS sub-system bundled in Microsoft Windows ME in 2000
- DOS-8 a.k.a. Mir-2, Russian spacecraft project of Salyut program in 2000
- Zvezda (ISS module), the final destination of the Russian DOS-8 module