CRC may refer to:

• Carboniferous Rainforest Collapse, an event at the end of the Carboniferous period
• Class-responsibility-collaboration card, used as a brainstorming tool in the design of object-oriented software
• Clinical research coordinator, responsible for conducting clinical trials
• Colorectal cancer, the development of cancer in the colon or rectum
• CRC Energy Efficiency Scheme, formerly the Carbon Reduction Commitment, a UK wide scheme designed to increase energy efficiency in large energy users
• CRC Handbook of Chemistry and Physics, a science reference handbook published by CRC Press
• CRC Standard Mathematical Tables, a mathematics reference handbook published by CRC Press
• Cyclic redundancy check, a type of hash function used to produce a checksum in order to detect errors in data storage or transmission

• California Rehabilitation Center, a state prison in the United States Of America
• Canadian Red Cross
• Capital Research Center, an American conservative non-profit organization
• Censorship Review Committee, which meets to discuss censorship in Singapore
• Central Revolutionary Committee (French: Comité révolutionnaire central), an extinct French political party
• Civilian Response Corps, deployable American federal civilian employees who provide reconstruction and stabilization assistance
• Commission for Rural Communities, a United Kingdom public body
• Committee on the Rights of the Child, which reports on implementation of the UN Convention on the Rights of the Child
  • Convention on the Rights of the Child, of the United Nations
• Communications Research Centre Canada, an agency of Industry Canada
• Communist, Republican, and Citizen Group, a French parliamentary group
• Community Rehabilitation Company, a private-sector suppliers of offender rehabilitation services in England and Wales
• Constitutional Research Council, a Unionist, pro-Brexit funding organisation in Scotland and Northern Ireland
• Control and Reporting Centre, part of the Air Force control and reporting system in most NATO countries
• Civil Rights Congress, a United States civil rights organization from 1946 until 1956

• CRC Churches International, a Pentecostal Protestant Christian denomination located primarily in Australasia
• Central Rabbinical Congress, a Haredi group
• Chicago Rabbinical Council
• Christian Reformed Church (disambiguation)
• Christian Revival Church, a Charismatic, Pentecostal and holistic Evangelical movement group
• Ligue de la contre-réforme catholique

• Cambridge Regional College, a further education college
• Center for Research and Communication, a Philippine think-tank that later became the University of Asia and the Pacific
• Cooperative Research Centre, a type of hybrid academic/industry research body existing in Australia
• Collaborative Research Centres, a type of publicly funded research body to advance basic research existing in Germany
• Cosumnes River College, a two-year community college in Sacramento, California
• Crowley's Ridge College, a Christian college in Paragould, Arkansas
• Cyclotron Research Center and Cyclotron Resource Center, particle accelerator complex at the University of Louvain, Belgium
• Georgia Tech Campus Recreation Center, the Rec center at Georgia Tech

• California Resources Corporation, a petroleum and natural gas company
• Chicago Recording Company, a recording studio in Chicago
• China Record Corporation, a large record company, based in Beijing
• China Resources (operated CRC Supermarkets)
• China Resources Cement, a cement company parented by China Resources
• Columbia Record Club, a mail-order music club offered by Columbia Records
• Computer Research Corporation, an early minicomputer manufacturer
• CRC-Evans, a pipeline-construction company owned by Stanley Black & Decker
• CRC Health Group, provider of addiction treatment and educational programs for adults and youth
• CRC Industries, a worldwide manufacturer of specialist industrial chemicals
• CRC Press, publisher, originally the Chemical Rubber Company
• Customer relation centre, a common company department

• Costa Rica (FIFA and IOC code)
• Camp Red Cloud, a US Army Camp in Uijeongbu, South Korea

• Canadian Rally Championship, a rally racing tournament
• Canadian Ringette Championships, a national ringette tournament
• Canadian Rugby Championship, a rugby union tournament
• Capablanca Random Chess, a 10x8 chess variant
• Collegiate Rugby Championship, a rugby sevens tournament

• Canada Research Chair, Canadian university research professorships
• Costa Rican colón, the ISO 4217 currency of Costa Rica
• Crc (protein), catabolite repression control protein
• Criminal record check

• Cross Racing Championship Extreme 2005 (CRC 2005), a car-racing game developed by Invictus Games