C-word, or c word may refer to:

• Cunt, a vulgarism for the female genitalia
• Cracker, racial slur directed at white people
• Cock (slang), a vulgarism for the penis
• Cancer, a euphemism for the illness
• The C-Word, a book and a BBC television drama by Lisa Lynch about her breast cancer
• "The C Word", an episode of Rollergirls
• "The C Word" (30 Rock), an episode of 30 Rock
• "The C-Word" (House), an episode of House
• "The 'C' Word", an episode of Herman's Head
• The C Word (film), a 2016 documentary about the effort to prevent cancer