Anastasio is both a given name and a surname. Notable people with the name include:

• Anastasio Alfaro (1865–1951), Costa Rican zoologist, geologist and explorer
• Anastasio Aquino (1792–1833), Salvadoran indigenous leader
• Anastasio Ballestrero (1913–1998), Italian prelate of the Roman Catholic Church
• Anastasio Bustamante (1780–1853), President of Mexico
• Anastasio Cuschieri (1872–1962), Maltese poet, politician, and philosopher
• Anastasio Somoza Debayle (1925–1980), President of Nicaragua
• Anastasio Somoza García (1896–1956), President of Nicaragua
• Anastasio Somoza Portocarrero (20th century), Nicaraguan anti-communist

• Albert Anastasia (1902–1957), born Albert Anastasio, American mobster
• Anthony Anastasio (1906–1963), American mobster and labor racketeer
• Armando Anastasio (born 1996), Italian footballer
• Kara Anastasio (21st century), American politician
• Michael R. Anastasio (born 1948), director of the Los Alamos National Laboratory
• Trey Anastasio (born 1964), American guitarist, composer, and vocalist
• Marco Anastasio (born 1997), simply known as Anastasio, Italian rapper and singer

• All pages with titles beginning with Anastasio
• All pages with titles containing Anastasio
• José Anastasio Torrens
• Anastasia
• Anastacio (name)
• Anastasia (surname)
• Anastasius (disambiguation)