The APC internal ribosome entry site (IRES) is an RNA element which is located in the coding sequence of the APC gene. APC is a tumour suppressor gene which is associated with the inherited disease adenomatous polyposis coli (APC). It is thought that IRES-mediated translation of APC is important for an apoptotic cascade.[1]
References
- ^ Heppner Goss K, Trzepacz C, Tuohy TM, Groden J (June 2002). "Attenuated APC alleles produce functional protein from internal translation initiation". Proceedings of the National Academy of Sciences of the United States of America. 99 (12): 8161–8166. doi:10.1073/pnas.112072199. PMC 123038. PMID 12034871.