4-Iodophenol (p-iodophenol) is an aromatic organic compound. A colorless solid, it is one of three monoiodophenols. 4-Iodophenol undergoes a variety of coupling reactions in which the iodine substituent is replaced by a new carbon group para to the hydroxy group of the phenol.[3] It is also used to enhance chemiluminescence for detection of cancer cells[4] and in the Eclox assay.
4-Iodophenol can be prepared from 4-aminophenol via the diazonium salt. An alternative synthesis involves reaction of salicylic acid with iodine, followed by decarboxylation.[5]
References
- ^ a b c Haynes, p. 3.324
- ^ Haynes, p. 5.93
- ^ a b "4-Iodophenol". Sigma-Aldrich.
- ^ "4-Iodophenol". Fisher Scientific.
- ^ Dains, F. B.; Eberly, Floyd (1935). "p-Iodophenol". Organic Syntheses. 15: 39. doi:10.15227/orgsyn.015.0039.
Cited sources
- Haynes, William M., ed. (2016). CRC Handbook of Chemistry and Physics (97th ed.). CRC Press. ISBN 9781498754293.