23S rRNA pseudouridine2604 synthase (EC 5.4.99.21, RluF, YjbC) is an enzyme with systematic name 23S rRNA-uridine2604 uracil mutase.[1][2][3] This enzyme catalyses the following chemical reaction
- 23S rRNA uridine2604 23S rRNA pseudouridine2604
The enzyme can, to a small extent, also react with uridine2605.
References
- ^ Del Campo M, Kaya Y, Ofengand J (November 2001). "Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli". RNA. 7 (11): 1603–15. PMC 1370202. PMID 11720289.
- ^ Alian A, DeGiovanni A, Griner SL, Finer-Moore JS, Stroud RM (May 2009). "Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome". Journal of Molecular Biology. 388 (4): 785–800. doi:10.1016/j.jmb.2009.03.029. PMC 2796871. PMID 19298824.
- ^ Sunita S, Zhenxing H, Swaathi J, Cygler M, Matte A, Sivaraman J (June 2006). "Domain organization and crystal structure of the catalytic domain of E.coli RluF, a pseudouridine synthase that acts on 23S rRNA". Journal of Molecular Biology. 359 (4): 998–1009. doi:10.1016/j.jmb.2006.04.019. PMID 16712869.
External links
- 23S+rRNA+pseudouridine2604+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
