Matthew Ebden and Jamie Murray defeated Hugo Nys and Jan Zieliński in the final, 6–4, 6–2 to win the doubles tennis title at the 2022 Winston-Salem Open.

Marcelo Arévalo and Matwé Middelkoop were the reigning champions, but chose not to participate.^[1]

	First round							Quarterfinals							Semifinals							Final
	1	N Mektić M Pavić	6	6
		A Nedovyesov A-u-H Qureshi	4	3				1	N Mektić M Pavić	77	65	[7]
		R Matos D Vega Hernández	3	4					H Nys J Zieliński	63	77	[10]
		H Nys J Zieliński	6	6												H Nys J Zieliński	6	77
	4	L Glasspool H Heliövaara	4	6	[10]										4	L Glasspool H Heliövaara	4	64
	WC	S Mansouri M Thomson	6	3	[5]			4	L Glasspool H Heliövaara	6	6
	PR	F Cabral F Škugor	4	77	[10]			PR	F Cabral F Škugor	4	3
		T Brkić M González	6	65	[8]																		H Nys J Zieliński	4	2
	WC	R Galloway A Lawson	6	5	[10]																	3	M Ebden J Murray	6	6
		N Lammons J Withrow	3	7	[6]			WC	R Galloway A Lawson	4	6	[6]
		S Gillé J Vliegen	65	4				3	M Ebden J Murray	6	3	[10]
	3	M Ebden J Murray	77	6											3	M Ebden J Murray	77	6
		A Behar G Escobar	6	1	[10]											S Bolelli M Melo	62	2
		F Martin J O'Mara	4	6	[7]				A Behar G Escobar	5	5
		S Bolelli M Melo	6	77					S Bolelli M Melo	7	7
	2	I Dodig A Krajicek	4	63

• Main draw