The 2006 Mississippi State Bulldogs football team represented Mississippi State University as a member of the Western Division of the Southern Conference (SEC) during the 2006 NCAA Division I FBS football season. Led by third-year head coach Sylvester Croom, the Bulldogs compiled an overall record of 3–9 with a mark of 1–7 in conference play, placing last out of six teams in the SEC's Western Division.^[1] Mississippi State played home games at Davis Wade Stadium in Starkville, Mississippi.

Date	Time	Opponent	Site	TV	Result	Attendance
August 31	7:00 pm	South Carolina	Davis Wade Stadium Starkville, MS	ESPN	L 0–15	50,277
September 9	11:30 am	No. 4 Auburn	Davis Wade Stadium Starkville, MS	LFS	L 0–34	43,640
September 16	6:00 pm	Tulane*	Davis Wade Stadium Starkville, MS		L 29–32	38,130
September 23	6:00 pm	at UAB*	Legion Field Birmingham, AL		W 16–10	36,104
September 30	11:30 am	at No. 9 LSU	Tiger Stadium Baton Rouge, LA (rivalry)	LFS	L 17–48	91,960
October 7	1:30 pm	No. 4 West Virginia*	Davis Wade Stadium Starkville, MS	PPV	L 14–42	40,327
October 14	1:30 pm	Jacksonville State*	Davis Wade Stadium Starkville, MS		W 35–3	38,635
October 21	12:00 pm	at Georgia	Sanford Stadium Athens, GA		L 24–27	92,746
October 28	1:30 pm	Kentucky	Davis Wade Stadium Starkville, MS		L 31–34	37,834
November 4	11:30 am	at Alabama	Bryant–Denny Stadium Tuscaloosa, AL (rivalry)	LFS	W 24–16	92,138
November 18	1:30 pm	No. 5 Arkansas	Davis Wade Stadium Starkville, MS		L 14–28	41,845
November 25	1:00 pm	at Ole Miss	Vaught–Hemingway Stadium Oxford, MS (Egg Bowl)		L 17–20	57,658
*Non-conference game Homecoming Rankings from AP Poll released prior to the game All times are in Central time

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