Luis Pacheco may refer to:

• Luis Alberto Pacheco (born 1968), Venezuelan football manager
• Luis Pacheco (director), Panamanian director, co-director of the 2019 film Operation Just Cause
• Luis Pacheco (footballer) (born 2008), Brazilian football midfielder
• Luis Pacheco (slave) (1800–1895), Afro-Spanish enslaved person
• Luis Pacheco de Narváez (1570–1640), Spanish writer