C. exasperatus may refer to a few different species. The specific epithet exasperatus means 'roughened.'

• Callinectes exasperatus, a crab in the family Portunidae
• Campylopus exasperatus [ceb; sv; vi; wikidata], a moss in the family Dicranaceae
• Cantharidus exasperatus [war; wikidata], a sea snail in the family Trochidae
• Carabus exasperatus [ceb; species; tr; wikidata], a beetle in the family Carabidae
• Centropogon exasperatus [wikidata], a plant in the family Campanulaceae
• Chiton exasperatus [ceb; nl; sv; war; wikidata], a marine mollusk in the family Chitonidae
• Chondracanthus exasperatus, a seaweed in the family Gigartinaceae
• Clavus exasperatus, a sea snail in the family Drilliidae
• Coccotrypes exasperatus [ceb; wikidata], a bark beetle in the family Curculionidae
• Colostethus exasperatus, a synonym for Hyloxalus exasperatus, a frog in the family Dendrobatidae
• Conotrachelodes exasperatus [ceb; wikidata], a weevil in the family Curculionidae
• Conotrachelus exasperatus [ceb; wikidata], a weevil in the family Curculionidae
• Cryptorhynchus exasperatus [ceb; wikidata], a weevil in the family Curculionidae