Highway 22 is a provincial highway in the Canadian province of Saskatchewan. The highway is split into two segments; the western segment is 77 kilometres (48 mi) long and runs from Highway 20 south of Bulyea to Highway 35 at Lipton, while the eastern segment is 154 kilometres (96 mi) long and runs from Highway 10 east of Balcarres to the Manitoba border where it continues as Provincial Road 478.^[4] The highway is split by a 42-kilometre (26 mi) gap that travels through Fort Qu'Appelle; the two segments are connected by Highways 35 and 10 and functions like an unsigned concurrency,^[2][3] though some maps show it as continuous.

The western terminus of the western segment of Highway 22 begins at Highway 20 less than 4 kilometres (2.5 mi) south of Bulyea. From there, the highway heads east towards Earl Grey.^[5] It then continues eastward and provides access to the communities of Southey (where it crosses the CanAm Highway (Highway 6)),^[6] Markinch,^[7] Cupar,^[8] and Dysart^[9] before ending at Highway 35 on the east side of Lipton.^[10]

The eastern segment of Highway 22 begins at Highway 10 8.2 kilometres (5.1 mi) east of Balcarres and travels south to Abernethy.^[11] About 3 kilometres (1.9 mi) south of Abernethy, just off Highway 22, is the historic Motherwell Homestead. Highway 22 heads east from Abernethy where it crosses Pheasant Creek — a tributary of the Qu'Appelle River — en route to a 1.6-kilometre (1 mi) concurrency with Highway 617 at Lemberg.^[12] Continuing east from Lemburg, it provides access to Neudorf^[13] and Killaly^[14] and has a 3.3-kilometre (2.1 mi) southbound concurrency with Highway 47. Continuing east from 47, the highway runs through Grayson^[15] en route to Highway 9 (Saskota Flyway) at which point it begins an 18-kilometre (11 mi) concurrency that runs south to Dubuc then east to Stockholm.^[16] Highway 9 drops south at that point and Highway 22 continues east to Esterhazy. About 2 kilometres (1.2 mi) east of Esterhazy, Highway 22 has a T junction with Highway 80^[17] in which Highway 80 is the straight-through road that heads north-east then north to Churchbridge and Highway 16 while Highway 22 turns south-east. After about 1.5 kilometres (0.9 mi), Highway 22 resumes its eastward travel to Highway 8. It has a 1.6 kilometres (1 mi) southbound concurrency with 8 before turning east and travelling straight to the border with Manitoba. In Manitoba, Highway 22 continues as Provincial Road 478.