The University of Illinois at Urbana-Champaign, also known as UIUC and the UofI (the officially preferred abbreviation), is a highly ranked engineering school and research campus of the University of Illinois; the campus is divided almost exactly between the cities of Urbana and Champaign. The university is composed of 16 colleges and institutes that offer more than 150 programs of study. There are approximately 28,000 undergraduates and 10,000 graduate students at Urbana-Champaign.

UIUC is the site of the National Center for Supercomputing Applications, which created the first graphical Web browser, Mosaic. The University also has the third largest academic library in the country.

It also hosts the InterVarsity Christian Fellowship's missions conference, Urbana, every three years.

• Marc Andreessen, co-creator of Mosaic, and later co-founder of Netscape
• John Anderson, congressman and 1980 presidential candidate
• Dorothy Day, founder of the Catholic Worker Movement
• Roger Ebert, movie critic
• Hugh Hefner, founder of Playboy magazine
• Jesse Jackson, civil rights activist
• Donald Johanson, anthropologist
• Robert Johnson, founder of BET Television Network
• Jack Kilby, inventor of the microchip, Nobel laureate (2000, Physics)
• Ang Lee, movie director
• Fidel Ramos, former president of the Philippines
• Andy Richter, actor/comedian

Football players Red Grange, Dick Butkus and Jeff George, as well as three NASA astronauts, are also graduates from the Urbana-Champaign campus.

11 alumni and nine professors from U of I have won the Nobel Prize, including two in 2003; professors Paul Lauterbur and Anthony Leggett won for their work in physiology/medicine and physics, respectively.

UIUC's sports teams, nicknamed the ''Fighting Illini'', compete in Division I (I-A for football) as a member of the Big Ten Conference.

• University of Illinois, Urbana-Champaign
• Official UofI athletics site