A syndrome is a set of medical signs and symptoms that are correlated with each other and, often, with a particular disease or disorder.

Syndrome may also refer to:

• Syndrome decoding, in coding theory
• Syndrome (The Incredibles), a fictional character
• Syndrome (video game series)
• Syndrome (TV series), a 2012 South Korean medical drama series
• Syndrome (video game), a 2016 survival horror game for PC and consoles
• Syndrome (Chihiro Onitsuka album), 2017
• Syndrome (Wonho album), 2025
• Pollination syndrome, a suite of flower traits that have evolved in response to natural selection imposed by different pollen vectors