Roman Zubarev

Roman A. Zubarev
Born1963 (age 62–63)
Stavropol, Russia
Alma materMoscow Engineering Physics Institute; Uppsala University
Known forElectron-capture dissociation; Isotopic resonance hypothesis; Proteomics; Alzheimer’s disease research; Origin of life studies
AwardsCurt Brunnée Award (2006); Biemann Medal (2007); Gold Medal, Russian Mass Spectrometry Society (2013); Berzelius Medal in Gold (2024)
Scientific career
FieldsChemistry; Physics; Biochemistry; Proteomics
InstitutionsCornell University; University of Southern Denmark; Uppsala University; Karolinska Institutet
Doctoral advisorBo Sundqvist

Roman A. Zubarev (born 1963) is a Russian-Swedish chemist and professor of medical proteomics in the Department of Medical Biochemistry and Biophysics at Karolinska Institutet, Stockholm, Sweden. His research spans mass spectrometry, proteomics, origin-of-life chemistry, disease biomarker discovery, and related fields.[1]

Education and career

Zubarev earned a Master of Science in Applied Physics at Moscow Engineering Physics Institute in 1986. He obtained a PhD in ion physics from Uppsala University in 1997, supervised by Bo Sundqvist.[2]

After his doctorate, he worked at Cornell University, where in 1997 he co-discovered electron-capture dissociation (ECD) of polypeptides with Fred McLafferty.[3] He later held posts at the University of Southern Denmark and Uppsala University, before becoming professor of medicinal proteomics at Karolinska Institutet.[1]

Research

Zubarev’s contributions include:

  • Electron-capture dissociation (ECD) — A mass spectrometry fragmentation technique for sequencing proteins and peptides.[4]
  • Isotopic resonance hypothesis — Proposes that specific isotopic compositions can accelerate biochemical reactions. Experimental studies on Escherichia coli growth have supported aspects of the hypothesis.[5]
  • Proteomics and biomarkers — Discovery of proteomic signatures in neurodegenerative diseases such as Alzheimer’s disease, along with developments in immunoproteomics and molecular biometry.[6]
  • Origin of life experiments — Research showing that abiotically synthesized mixtures, such as those produced in Miller–Urey type experiments, can sustain bacterial growth.[7]

Awards

Zubarev has received several international awards:

  • Curt Brunnée Award (2006)[8]
  • Biemann Medal, American Society for Mass Spectrometry (2007)[9]
  • Gold Medal, Russian Mass Spectrometry Society (2013)[10]
  • Berzelius Medal in Gold, Swedish Chemical Society (2024)[11]

Selected publications

References

  1. ^ a b "Roman Zubarev – Karolinska Institutet". Karolinska Institutet. Retrieved 18 September 2025.
  2. ^ Ilag, L. L.; Zubarev, R. A. (2010). "The role of mass spectrometry in the postgenomic era". Mass Spectrometry Reviews. doi:10.1002/mas.20282. PMID 20661940.
  3. ^ Zubarev, R. A.; Kelleher, N. L.; McLafferty, F. W. (1998). "Electron Capture Dissociation of Multiply Charged Protein Cations. A Non-ergodic Process". Journal of the American Chemical Society. 120 (13): 3265–3266. Bibcode:1998JAChS.120.3265Z. doi:10.1021/ja973478k.
  4. ^ Zubarev, R. A.; Horn, D. M.; Fridriksson, E. K.; Kelleher, N. L.; Kruger, N. A.; Lewis, M. A.; Carpenter, B. K.; McLafferty, F. W. (2000). "Electron capture dissociation for structural characterization of multiply charged protein cations". Analytical Chemistry. 72 (3): 563–573. doi:10.1021/ac990811p.
  5. ^ Xie, X.; Zubarev, R. A. (2015). "Isotopic resonance hypothesis: experimental verification by Escherichia coli growth measurements". Scientific Reports. 5: 9210. doi:10.1038/srep09210. PMC 4366856. PMID 25790763.
  6. ^ Yang, H.; Lyutvinskiy, Y.; Herukka, S. K.; Soininen, H.; Rutishauser, D.; Zubarev, R. A. (2014). "Prognostic polypeptide blood plasma biomarkers of Alzheimer's disease progression". Journal of Alzheimer's Disease. 40 (3): 659–666. doi:10.3233/JAD-131847. PMID 24577456.
  7. ^ Xie, X.; Backman, D.; Lebedev, A. T.; Artaev, V. B.; Jiang, L.; Ilag, L. L.; Zubarev, R. A. (2015). "Primordial soup was edible: abiotically produced Miller–Urey mixture supports bacterial growth". Scientific Reports. 5 14338. Bibcode:2015NatSR...514338X. doi:10.1038/srep14338. PMC 4585927. PMID 26354806.
  8. ^ "Curt Brunnée Award". International Mass Spectrometry Conference. Retrieved 18 September 2025.
  9. ^ "Biemann Medal Recipients". American Society for Mass Spectrometry. Retrieved 18 September 2025.
  10. ^ "Roman Zubarev". ISOREA. Retrieved 18 September 2025.
  11. ^ "KI researcher Roman Zubarev awarded the Berzelius Medal in Gold". Karolinska Institutet News. 21 March 2024. Retrieved 18 September 2025.
allikas: http://en.wikipedia.org/wiki/Roman_Zubarev