Big Mama may refer to:

• Big Mama, a character in the 2018 cartoon series Rise of the Teenage Mutant Ninja Turtles
• Big Mama (film), a 2000 Oscar-winning American film about grandparents raising their grandchildren
• Big Mama (band), a band of four female pop/R&B singers in South Korea
• "Big Mama" (song), by Latto
• Big Mama, a character in the 1981 film The Fox and the Hound
• Big Mama, a character in the anime and manga series Sorcerer Hunters
• Big Mama, a nickname of EVA in Metal Gear Solid 4: Guns of the Patriots
• Big Mama, a nickname of Josephine Joseph, matriarchal character in the Soul Food film and television series
• "Big Mama (Unconditional Love)", a song by LL Cool J from his 2002 album 10
• Big Mama Thornton (1926–1984), American blues singer
• BigMama, the stage name of Italian rapper Marianna Mammone (born 2000)

• Big Mama, a name for Mary, mother of Jesus in the Mama Tata religion
• Big Mama, a nickname of JoAnne Carner, former LPGA golfer
• Big mama, a colloquial name for Internet censors on web bulletin boards in the People's Republic of China
• "Big Mama", a nickname given to a specimen of Citipati

• Big Momma's House, a 2000 series of American comedy films
• Chinese dama, a term that refers to Chinese middle-aged women