Zardini is an Italian surname. Notable people with the surname include:

• Elsa Matilde Zardini (1949–2020), Paraguayan/Argentinian botanist
• Edoardo Zardini (alpine skier) (born 1976), an Italian alpine skier
• Edoardo Zardini (cyclist) (born 1989), an Italian cyclist
• Ernesto Zardini (1908-1934), Italian ski jumper
• Mirko Zardini (born 1955), Italian curator
• Sergio Zardini (1931–1966), Italian bobsledder