The following highways are numbered 59:

• E59 European route E59

• Bells Line of Road

• Alberta Highway 59
• Manitoba Highway 59

• G59 Expressway

• EO59 road

• National Highway 59 (India)

• Road 59

• Autostrada A59

• Hakodate-Esashi Expressway

• National Route 59

• New Zealand State Highway 59

• N59 highway (Philippines)

• British A59

• Interstate 59
• U.S. Route 59
• Alabama State Route 59
• Arkansas Highway 59
• California State Route 59
• Colorado State Highway 59
• Connecticut Route 59
• Florida State Road 59
  • County Road 59 (Jefferson County, Florida)
  • County Road 59 (Leon County, Florida)
  • County Road 59 (Wakulla County, Florida)
• Georgia State Route 59
• Illinois Route 59
• Indiana State Road 59
• Kentucky Route 59
• Louisiana Highway 59
• Maryland Route 59 (former)
• M-59 (Michigan highway)
• Missouri Route 59
• Montana Highway 59
• Nebraska Highway 59
  • Nebraska Link 59B
• Nevada State Route 59 (former)
• New Jersey Route 59
  • County Route 59 (Bergen County, New Jersey)
  • County Route 59 (Ocean County, New Jersey)
• New Mexico State Road 59
• New York State Route 59
  • County Route 59 (Chautauqua County, New York)
  • County Route 59 (Dutchess County, New York)
  • County Route 59 (Herkimer County, New York)
  • County Route 59 (Jefferson County, New York)
  • County Route 59 (Madison County, New York)
  • County Route 59 (Orange County, New York)
  • County Route 59 (Oswego County, New York)
  • County Route 59 (Putnam County, New York)
  • County Route 59 (Rensselaer County, New York)
  • County Route 59 (Schoharie County, New York)
  • County Route 59 (St. Lawrence County, New York)
  • County Route 59 (Steuben County, New York)
  • County Route 59 (Suffolk County, New York)
  • County Route 59 (Sullivan County, New York)
  • County Route 59 (Washington County, New York)
  • County Route 59 (Wyoming County, New York)
• North Carolina Highway 59 (former)
• North Dakota Highway 59
• Ohio State Route 59
• Oklahoma State Highway 59
  • Oklahoma State Highway 59B
• Pennsylvania Route 59
• South Carolina Highway 59
• South Dakota Highway 59 (former)
• Tennessee State Route 59
• Texas State Highway 59
  • Texas State Highway Spur 59
  • Farm to Market Road 59
  • Texas Park Road 59
• Utah State Route 59
• Virginia State Route 59
• West Virginia Route 59
• Wisconsin Highway 59
• Wyoming Highway 59

• List of highways numbered 59A
• A59 (disambiguation)