Glucose-6-phosphate exchanger SLC37A1 is a protein that in humans is encoded by the SLC37A1 gene.[5] SLC37A1 locates to the membrane of the endoplasmic reticulum (ER), and is a glucose 6-phosphate:inorganic phosphate antiporter, transporting glucose 6-phosphate from the cytoplasm into the lumen of the ER, while transporting phosphate in the opposite direction.[6]

Unlike the related SLC37A4 protein, SLC37A1 does not appear to be involved in blood glucose homeostasis,[7] but does appear to regulate phosphate levels in the milk of cows, with flow-on effects on the volume of milk produced.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160190 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024036 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Solute carrier family 37 (glucose-6-phosphate transporter), member 1".
  6. ^ "SLC37A1 - Glucose-6-phosphate exchanger SLC37A1 - Homo sapiens (Human) - SLC37A1 gene & protein".
  7. ^ Pan CJ, Chen SY, Jun HS, Lin SR, Mansfield BC, Chou JY (2011). "SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters". PLOS ONE. 6 (9): e23157. Bibcode:2011PLoSO...623157P. doi:10.1371/journal.pone.0023157. PMC 3176764. PMID 21949678.
  8. ^ Kemper KE, Littlejohn MD, Lopdell T, Hayes BJ, Bennett LE, Williams RP, Xu XQ, Visscher PM, Carrick MJ, Goddard ME (2016). "Leveraging genetically simple traits to identify small-effect variants for complex phenotypes". BMC Genomics. 17 (1): 858. doi:10.1186/s12864-016-3175-3. PMC 5094043. PMID 27809761.

Further reading


Allikas: https://en.wikipedia.org/wiki/SLC37A1
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