Caspase 4 is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue (LEVD-), and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and the murine homolog caspase 11), with a role in the immune system.[1]

The anti-inflammatory drug indoprofen is an inhibitor of the activity of the caspase-4 enzyme.[2]

See also

References

  1. ^ Martinon F, Tschopp J (2007). "Inflammatory caspases and inflammasomes: master switches of inflammation". Cell Death Differ. 14 (1): 10–22. doi:10.1038/sj.cdd.4402038. PMID 16977329.
  2. ^ Smith C, Soti S, Jones Torey A, Nakagawa A, Xue D, and Yin H (2017). "NSAIDs are Caspase Inhibitors". Cell Chem Biol. 24 (3): 281–292. doi:10.1016/j.chembiol.2017.02.003. PMC 5357154. PMID 28238723.
  • The MEROPS online database for peptidases and their inhibitors: C14.007


Allikas: https://en.wikipedia.org/wiki/Caspase_4
No tags for this post.