William Browne may refer to:

• William Browne (Mayor of the Calais Staple) (1410–1489), Lord Mayor and Merchant of the Staple of Calais, France
• Sir William Browne (died 1514), Lord Mayor of London
• Sir William Browne (died 1507), Lord Mayor of London
• William Browne (judge) (1737–1802), Justice of the Massachusetts Superior Court of Judicature
• William Browne (MP for Haslemere), English politician who sat in the House of Commons between 1614 and 1622
• William Browne (burgess) (1630-1705), Virginia colonial planter, officer and politician
• William Browne (MP for Kerry) (1791–1876), Irish politician in the UK Parliament
• William James Browne (1815–1894), pastoralist and politician in South Australia
• William Browne (New South Wales politician) (1842–1916), Australian politician
• William M. Browne (1827–1883), soldier and cabinet member of the Confederate States of America
• William Alfred Browne (1831–1904), British civil servant
• William Joseph Browne (1897–1989), Newfoundland and Canadian politician
• William Browne (Irish politician) (fl. 1930s), Irish Fianna Fáil politician
• William Browne (Queensland politician) (1846–1904), gold miner and member of the Queensland Legislative Assembly

• William Browne (cricketer) (1898–1980), Australian cricketer
• Willie Browne (1936–2004), Irish football player
• Horsey Browne (William F. Browne, 1903–1931), Irish rugby player

• William Browne (poet) (c. 1590–c. 1645), English poet
• William Browne (physician) (1692–1774), English physician
• William George Browne (1768–1813), British traveller
• William Phineas Browne (1804–1869), American lawyer and coal mining pioneer
• William A. F. Browne (1805–1885), British psychiatrist
• William F. Browne (died 1867), American military photographer
• William James Browne (1815–1894), grazier, pastoralist and politician in South Australia
• William Rowan Browne (1884–1975), Australian geologist
• William Denis Browne (1888–1915), British composer, pianist, organist and music critic (last name is Denis Browne, though he is sometimes incorrectly referred to as "William Browne")
• William D. Browne (fl. 1940s), U.S. Army officer who discovered Nazi membership files
• William Washington Browne (1849–1897), former slave and Union soldier

• William Brown (disambiguation)