William Blackburn (1750–1790) was an English architect.
William Blackburn may also refer to:
- W. Jasper Blackburn (1820–1899), American politician
- William M. Blackburn (1828–1898), American university president
- William Blackburn (cricketer) (1888–1941), English cricketer
- William Blackburn (footballer) (1911–1979), English footballer
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