The abbreviation TSE can refer to:

• TSE (examination), Test of Spoken English
• Toulouse School of Economics, in Toulouse, France
• Turku School of Economics, in Turku, Finland

• Taiwan Stock Exchange
• Tallinn Stock Exchange
• Tehran Stock Exchange
• Tirana Stock Exchange
• Tokyo Stock Exchange
• Toronto Stock Exchange, now TSX

• Testicular self-examination
• Transmissible spongiform encephalopathy
• Turbo spin echo, a sequence of magnetic resonance imaging

• Tse (surname), a Chinese surname, the Cantonese spelling of Xie (谢)
• T. S. Eliot, Anglo-American poet
• Thomas Sayers Ellis, American poet
• Thomas Saunders Evans, was an eminent British scholar of and translator into Latin and Ancient Greek

• IEEE Transactions on Software Engineering
• The SemWare Editor, a text editor for DOS, OS/2, Windows, and Linux
• Torque Shader Engine, a video game engine used in Xbox and Xbox 360 console systems
• Truck stop electrification, a plan to reduce idling of highway trucks
• Windows NT 4.0 Terminal Server Edition, a Microsoft operating system that provided remote access

• Tse (Cyrillic) (Ц, ц), a letter of the Cyrillic alphabet
• Tse Monastery, a 4th-century Christian monastery in Egypt
• Superior Electoral Court (Portuguese: Tribunal Superior Eleitoral, TSE), the highest electoral court in Brazil
• Supreme Electoral Court (disambiguation) (Spanish: Tribunal Supremo Electoral, TSE), a name given to a number of different courts in South America
• Texas South-Eastern Railroad, a Class III Texas railroad
• Total solar eclipse, a rare astronomical event
• Total Sports Entertainment, a sports entertainment and game software company
• Turkish Standards Institution (Turkish: Türk Standardları Enstitüsü, TSE), a public standards organization in Turkey
• An old IATA airport code for Nursultan Nazarbayev International Airport, now NQZ

• Tsetse (disambiguation)