Thomas, Tommy or Tom Cooke may refer to:

• Thomas Cooke (mayor) (died 1478), Lord Mayor of London
• Sir Thomas Cooke (c. 1648–1709), Governor of East India Company and MP for Colchester
• Thomas Cooke (banker) (died 1752), English merchant and banker
• Thomas Cooke (author) (1703–1756), English translator of the classics
• Thomas B. Cooke (1778–1853), United States Representative from New York
• Thomas Simpson Cooke (1782–1848), Irish composer, singer and theatre musician
• Thomas Taplin Cooke (1782–1866), English showman
• Thomas Cooke (actor) (1786–1864), English actor
• Thomas Cooke (bishop) (1792–1870), Canadian Roman Catholic bishop
• Thomas Cooke (scientific instrument maker) (1807–1868), telescope maker, founder of T. Cooke & Sons
• Thomas Cooke (British Army officer) (1841–1912), British general
• Thomas Cooke (English footballer) (fl. 1880s), English footballer for Notts County
• Thomas Cooke (soldier, born 1881) (1881–1916), Australian recipient of the Victoria Cross
• Thomas Cooke (soccer) (1885–1964), American football player, and member of the 1904 US Olympic Team
• Thomas F. Cooke (1863–1941), Iowa and California banker and Los Angeles City Council member
• Thomas Cooke (footballer, born 1913) (1913–1974), English footballer for Bournemouth & Boscombe Athletic and Mansfield Town
• Thomas H. Cooke Jr., mayor of East Orange, New Jersey, 1978–1986

• T. Cooke & Sons, a mathematical instrument company
• Thomas Coke (disambiguation)
• Thomas Cook (disambiguation)
• Sir Thomas Cookes, 2nd Baronet
• Thomas Cook (1808–1892), travel entrepreneur