Thiocoraline is a microbial natural product of the depsipeptide class. Thiocoraline was isolated from the mycelium cake of a marine actinomycete strain L-13-ACM2-092.[1] In vitro, thiocoraline causes an arrest in G1 phase of the cell cycle and decreases the rate of S phase progression towards G2/M phase.[2] Thiocoraline is likely to be a DNA replication inhibitor. Thiocoraline is produced on a nonribosomal peptide synthetase (NRPS) assembly line.[3]

References

  1. ^ Romero F, Espliego F, Pérez Baz J, García de Quesada T, Grávalos D, de la Calle F, Fernández-Puentes JL (September 1997). "Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activities". The Journal of Antibiotics. 50 (9): 734–7. doi:10.7164/antibiotics.50.734. PMID 9360617.
  2. ^ Erba E, Bergamaschi D, Ronzoni S, Faretta M, Taverna S, Bonfanti M, Catapano CV, Faircloth G, Jimeno J, D'Incalci M (June 1999). "Mode of action of thiocoraline, a natural marine compound with anti-tumour activity". British Journal of Cancer. 80 (7): 971–80. doi:10.1038/sj.bjc.6690451. PMC 2363046. PMID 10362104.
  3. ^ Lombó F, Velasco A, Castro A, de la Calle F, Braña AF, Sánchez-Puelles JM, Méndez C, Salas JA (February 2006). "Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two Streptomyces species". ChemBioChem. 7 (2): 366–76. doi:10.1002/cbic.200500325. PMID 16408310. S2CID 28760297.
Allikas: https://en.wikipedia.org/wiki/Thiocoraline
No tags for this post.