Tarbell Brook is a 10.1-mile-long (16.3 km)^[1] stream located in southwestern New Hampshire and northern Massachusetts in the United States. It is a tributary of the Millers River, itself a tributary of the Connecticut River, which flows to Long Island Sound.

Tarbell Brook rises in the western part of Rindge, New Hampshire, at the outlet of Pearly Lake,^[2] and flows south to the Damon Reservoirs. The brook then passes into Winchendon, Massachusetts, reaching the Millers River approximately 2 miles (3 km) west of the town center.

It bears the name of Lieutenant Samuel Tarbell (1744-1828), a Revolutionary War Minuteman who settled in Rindge with his wife Beatrice Carter in 1773, soon thereafter building a watermill at the outflow of Pearly Lake (formerly known as Tarbell Pond). Although the mill is long gone, Tarbell's Cape Cod style house nearby still presides over Route 119.

• List of rivers of Massachusetts
• List of rivers of New Hampshire