Talopeptin is a chemical compound derived from cultures of Streptomyces. It is a known reversible inhibitor of thermolysin[1] and is expected to inhibit other metalloproteinases.[2][3] Chemically, talopeptin differs from its closely related peptidase inhibitor phosphoramidon by a single stereocenter.

References

  1. ^ Kitagishi, Keiko; Hiromi, Keitaro (1984). "Inhibitory spectrum of talopeptin (MKI), a specific inhibitor of thermolysin". Agricultural and Biological Chemistry. 48 (5): 1287–91. doi:10.1271/bbb1961.48.1287.
  2. ^ Fukuhara, Kenichi; Murao, Sawao; Nozawa, Tsunenori; Hatano, Masahiro (1982). "Structural elucidation of talopeptin (MK-I), a novel metallo proteinase inhibitor produced by Streptomyces mozunensis MK-23". Tetrahedron Letters. 23 (22): 2319–22. doi:10.1016/S0040-4039(00)87331-1.
  3. ^ Kitagishi, Keiko; Hiromi, Keitaro; Oda, Kohei; Murao, Sawao (1983). "Equilibrium study on the binding between thermolysin and Streptomyces metalloprotease inhibitor, talopeptin (MKI)". Journal of Biochemistry. 93 (1): 47–53. doi:10.1093/oxfordjournals.jbchem.a134176. PMID 6341369.
Allikas: https://en.wikipedia.org/wiki/Talopeptin
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