TLE may stand for:

• The Living End, an Australian band formed in 1994
• Star Trek: The Lost Era, a novel series in the Star Trek franchise
• Lost Experience, a game based on the Lost television series

• Temporal lobe epilepsy, the most common form of focal seizure, originating in the temporal lobe of the brain

• Kimber Custom TLE II, a model of the Kimber Custom handgun
• Temporal light effects, wanted or unwanted effects caused by light modulations
• Total lunar eclipse, an astronomical event
• Transient luminous event, or upper-atmospheric lightning, a weather phenomenon
• Two-line element set, a format for distributing orbital element data

• Technology and Livelihood Eco-friendly, part of an educational curriculum in the Philippines
• The London Economic, a left-wing digital newspaper based in the UK
• The Last Elegy, a Brazilian esports team