T-bone is a steak of beef.

T-Bone may also refer to:

• Trombone (nickname)
  • T-Bone Concerto, a concerto for trombone and wind orchestra by Johan de Meij
• The T-Bones, an American instrumental pop/rock group
• "T-Bone", a song from the album Re·ac·tor by Neil Young and Crazy Horse

• T Bone Burnett (born 1948), American musician, songwriter and producer
• T-Bone Slim (1890–1942), pen name for American poet, songwriter and labour activist Matti Valentine Huhta
• T-Bone Walker (1910–1975), American blues guitarist, singer and songwriter
• T-Bone Wilson, Guyanese-British actor, dramatist and poet
• T-Bone (rapper), American Christian rapper
• Tony "T-Bone" Bellamy (1946–2009), lead guitarist, pianist and vocalist for the band Redbone
• Tom "T-Bone" Stankus, American children's musician
• Tom "T-Bone" Wolk (1951–2010), American bassist
• Teebone, British UK garage/drum and bass producer and DJ

• Captain T-Bone, from the One Piece manga series
• Chance "T-Bone" Furlong, an anthropomorphic feline from the series SWAT Kats: The Radical Squadron
• T-Bone, an arsonist and George Bluth's cell-mate in "Top Banana", a season 1 episode of Arrested Development
• T-Bone, a canine character in the television series Clifford the Big Red Dog
• T-Bone Mendez, in the videogame Grand Theft Auto: San Andreas
• Raymond Kenney, also known as T-Bone from Watch Dogs series
• T-Bone, a skeleton who is a minor character in Skylanders series
• T-Bone, a skeleton who is a villain in the video game Cuphead
• T-Bone, a bull villager from Animal Crossing, a video game series
• T-Bone, a character in the 2017 film Paddington 2
• T Bone, the protagonist of T Bone N Weasel, a 1992 television film directed by Lewis Teague

• Kansas City T-Bones, a minor league baseball team
• T-bone accident, where the front or rear of a moving vehicle crashes into the side of another vehicle
• T-Bone, a nickname for the Beechcraft Twin Bonanza, a light twin-engined airplane