St. Xavier or St. Xavier's may refer to:
- St. Francis Xavier (1506–1552), a Spanish Roman Catholic saint
- St. Xavier, Montana, a census-designated place in the United States
- St. Xavier's Church, Kottar, a church in Tamil Nadu, India
- St. Xavier's Church, Peyad, a church in Kerala, India
- St. Xavier's School, Delhi, a school in Delhi, India
- St. Xavier's University, Kolkata, a Jesuit university located in New Town, Kolkata, India
- St. Xavier's College, Mumbai, a private, Catholic college in Mumbai, India
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