Spike Island may refer to:

• Spike Island (Tasmania)

• Spike Island, Bristol, an area of the English port city of Bristol, adjoining the city centre
• Spike Island, Widnes, a park in Widnes
• Spike Island (Southampton), the area bounded by the River Itchen and River Hamble in Hampshire
• Spike Island, former name for Northumberland Heath, London
• Spike Island railway station, a workman's platform situated off the Great Northern Railway's main line south of Doncaster

• Spike Island, County Cork, an island in Cork Harbour, Ireland

• Spike Island (concert), a 1990 concert headlined by the Stone Roses in Widnes, England
• Spike Island (film), a 2012 British comedy film based on the 1990 concert
• Spike Island Artspace, a centre for contemporary art in Bristol, England