T5 or T-5 can refer to:

• Fifth thoracic vertebrae
• Fifth spinal nerve
• bacteriophage T5, a bacteriophage

• Ford T5, a Ford Mustang built for export to Germany
• Fuji T-5, a 1988 Japanese turboprop-driven primary trainer aircraft
• Trikke 5, a 3 wheeled cambering vehicle
• Volkswagen Transporter, a van
• a model of the OS T1000 train of the Oslo Metro
• Île-de-France tramway Line 5, one of the Tramways in Île-de-France
• Borg-Warner T-5 transmission
• T5 engine, a line of Volvo inline-five turbocharged engines.

• Turkmenistan Airlines, IATA airline designator
• Terminal 5 at JFK Airport in New York City
• London Heathrow Terminal 5

• Tele 5 (Poland), a TV channel
• Thunderbird 5, an episode in the Thunderbird TV series
• In topology, a completely normal and hausdorff space
• Telecinco, a Spanish TV channel
• The fifth edition of the role-playing game Traveller
• Tekken 5, a fighting video game
• Terminator Genisys, the fifth film in the Terminator film franchise

• T5 fluorescent lamp
• Tungsten T5, a PDA
• Rebel T5, the model name used in the Americas for the Canon EOS 1200D digital camera
• Tapestry 5, a Java-based Web application framework