Sixth sense or variants may refer to:

• Biological senses other than the five traditionally understood in many cultures — taste, smell, touch, sound, & sight. Some are internal, for example our sense of balance, or sense of pain or spatial orientation. Animals can also have senses for temperature, for echolocation, electric and/or magnetic fields, moisture, polarized light, and other phenomena.

• Extrasensory perception (ESP) — narrowly this refers to psychic powers, or even more specifically to mind-reading. More generally, it can refer to any sensing modality which is seen as super-human, whether it is explainable by science or not.

• The Sixth Sense, a 1999 film
• Sixx Sense, an American radio show hosted by Nikki Sixx

• "A Sixth Sense", 24 Hours in Police Custody series 3, episode 5
• "A Sixth Sense", The Haves and the Have Nots season 7, episode 18
• "Sixth Sense", Death Valley Days season 2, episode 16
• "Sixth Sense", Hart to Hart season 1, episode 18
• "Sixth Sense", Paranormal State season 1, episode 1
• "Sixth Sense", Police Woman season 4, episode 15
• "Sixth Sense", Supersense episode 1
• "Sixth Sense", ThunderCats (1985 TV series) season 1, episode 26
• "The Sixth Sense", First Love (2022 TV series) episode 6
• "The Sixth Sense", Give My Head Peace series 5, episode 4
• "The Sixth Sense", Happy Days season 8, episode 9
• "The Sixth Sense", Mine episode 5

• The Sixth Sense (American TV series), a 1972 American TV series
• The Sixth Sense (Thai TV series), a 2012–2013 Thai TV series
• Sixth Sense (TV series), a 2020 South Korean variety television program
• Sixth Sense (game show), a 2018 Indian TV series

• "The Sixth Sense", an 1898 short story by Margaret Sutton Briscoe
• The Sixth Sense, a 1905 novel by Adeline Sergeant
• The Sixth Sense: Its Cultivation and Use, a 1911 non-fiction book by Charles Henry Brent
• The Sixth Sense, a 1915 novel by Stephen McKenna
• The Sixth Sense, a 1965 novel by Konrad Bayer
• Pisces: Sixth Sense, a 1995 novel by Jahnna N. Malcolm
• The Sixth Sense, a novelization of the 1999 film by Peter Lerangis

• Sixth Sense, a music act associated with Storyhill

• Sixth Sense (Brown Eyed Girls album), 2011
• The Sixth Sense (Lee Morgan album), 1968
• The Sixth Sense (Don Pullen album), 1985
• The Sixth Sense, a 2013 album by Ai Kuwabara
• El Sexto Sentido (The Sixth Sense), a 2006 album by Thalía

• "Sixth Sense" (Brown Eyed Girls song), 2011
• "The 6th Sense", a 2000 song by Common
• "Sixth Sense", a song by Chicago from the 1975 album Chicago VIII
• "Sixth Sense", a song by Ofra Haza from the 1997 album Ofra Haza
• "Sixth Sense", a song by Royal Hunt from the 2010 album X
• "Sixth Sense", a song by Donna Lewis from the 2002 album Be Still
• "Sixth Sense", a song by Imelda May from the 2017 album Life Love Flesh Blood
• "Sixth Sense", a song by Wire from the 1990 album Manscape

• SixthSense, a 1990s gesture-based wearable computer system
• HTC Sense version 6, nicknamed "Sixth Sense"

• All pages with titles containing Sixth sense

• Five senses (disambiguation)