Sissa may refer to:
People
- Giulia Sissa (born 1954), Italian classical scholar and historian of philosophy
- Sissa (mythical brahmin), legendary Indian inventor of chess
Places
- Sissa Trecasali, a comune in Parma, Emilia-Romagna, Italy
- Sissa, Sissa Trecasali, a frazione
- Sissa River, Flores, East Nusa Tenggara, Indonesia
Other
- SISSA (International School for Advanced Studies), Trieste, Italy
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