Severino is an Italian, Spanish, and Portuguese given name and sometimes surname:

• Saint Severinus of Noricum (c.410–482), a Roman Catholic saint:
• Severin of Cologne, a Roman Catholic saint
• Emanuele Severino (1929–2020), Italian philosopher
• Isabelle Severino (born 1980), French gymnast
• Lucas Severino (born 1979), Brazilian footballer
• Luis Severino (born 1994), Dominican baseball player
• Paola Severino (born 1948), Italian Justice Minister and University Rector
• Pedro Severino (born 1993), Dominican baseball player
• Robson Severino da Silva (born 1983), Brazilian footballer
• Roger Severino, United States lawyer
• Sérgio Severino da Silva (born 1978), Brazilian footballer

• Severino Albarracín (1851–1878), Spanish anarchist
• Severino Antinori (born 1945), Italian gynecologist and embryologist
• Severino Cavalcanti (1930–2020), Brazilian politician
• Severino Compagnoni (1914–2006), Italian cross country skier
• Severino Di Giovanni (1901–1931), Italian anarchist
• Severino Gazzelloni (1919–1992), Italian flutist
• Severino Montano (1915–1980), Filipino playwright, director and actor
• Severino Poletto (born 1933), Italian cardinal
• Severino dos Ramos Durval da Silva (born 1980), Brazilian footballer
• Severino Reija (born 1938), Spanish footballer
• Severino Reyes (1861–1942), Filipino writer, playwright and director
• Severino Santiapichi (1926–2016), Italian magistrate and writer

• San Severino - Various places in Italy
• Severino (album), album by Brazilian band Os Paralamas do Sucesso released in 1994